In looking at this map, one can see how the lower order concepts are subsumed under higher order concepts, how. Learning with concept and knowledge maps 415 a concept map can be regarded as a type of graphic organizer that is distinguished by the use of labeled nodes denoting concepts and links denoting relationships among concepts. Such analysis applied to gene expression data is often referred to as gene. New horizons in adult education and human resource development volume 24, numbers 2 4 33 figure 1, a concept map of a concept map, depicts these three processes. Use our diagram tool to edit this and see the various outcomes of your ideasyou can edit this template and create your own diagram. A network analysis of concept maps of triangle concepts. The elucidation of biological concepts enriched with. Pdf role of the tmprss2erg gene fusion in prostate cancer. Organize the major points and rank the key words from the most abstract and inclusive to the most concrete and specific. The theory underlying concept maps and how to construct and. Role of the tmprss2erg gene fusion in prostate cancer. Integrative molecular concept modeling of prostate cancer. Begin analysis in oncomine with validating a dasatinib signature 1.
A summary of literature pertaining to the use of concept. A concept map is a nodelink diagram showing the semantic relationships among concepts. Sets of genes representing some aspect of biology derived from both. Social network analysis is explored here as a supplement to concept mapping. The technique for constructing concept maps is called concept mapping.
Spider concept map thespider concept map is organized by placing the central theme or unifying factor in the center of the map. Molecular concept map analysis of the overexpressed in rwpeerg compared to rwpegus signature ringed yellow node. Concept mapping has also been shown to increase higher order learning. Consensus brand maps include the core brand associations that define the brands image and show which brand associations are linked directly to the brand, which. Exploring the heat maps of the four analyses reveals genes with the most. Pdf dna microarrays have been widely applied to cancer transcriptome analysis. A concept map is a good way to begin the research process. From the results obtained, a selection was made of those works which best encompass the lines. An introduction to concept mapping ideas are like rabbits. We computed pairwise association analysis on all,364 molecular concepts and identified 290,000 significant associations, generating hypotheses that link cancer types and subtypes, pathways, mechanisms, and drugs. A network analysis of concept maps of triangle concepts jin haiyue national institute of education, singapore wong khoon yoong national institute of education, singapore mathematics educators and mathematics standards of curriculum have emphasised the. Th e main concept uses a triangle, major subconcepts use a rectangle, and. Molecular concepts analysis, interactome analysis, and. Importantly, oncomine concepts map analysis identified a network of invasion related concepts that shared enrichment with our overexpressed in rwpeetv5, rwpeerg, and rwpeetv1 concepts, such as upregulated genes in hmlht or mcf10a breast cells expressing stat3c or, 5.
Concept mapping in this module you will learn what a concept map is and how to create one for your research. Rapid drug target ranking system for drug discovery. Using concept maps as a research tool in science education research richard j. In this book, however, we use the term only to refer. Introduction to oncomine cancer biology and therapeutics program.
Creately diagrams can be exported and added to word, ppt powerpoint, excel, visio or any other. We used oncomine concepts edition to explore gene expression results related to. Normalized data are loaded into the oncomine database for analysis. A network view of selected molecular concepts enriched for genes differentially expressed upon mek inhibition of mutant braf cells.
The concept map method allows a person or a team to collect their ideas about a central topic in a visual way. Outwardly radiating subthemes surround the center of the map. The visualize tab now contains a heat map with data for egfr. Begin analysis in oncomine by adding filters and performing metaanalysis for target discovery 1. A concept map is a diagram or graphical tool that visually represents relationships between concepts and ideas. Most concept maps depict ideas as boxes or circles also called nodes, which are structured hierarchically and connected with lines or arrows also called arcs. Pairwise concepts association analysis was performed between all cluster concepts fishers exact test, and the segregation panel modules of the same cancer type. The links in a concept map may be labeled or unlabeled, directional or nondirectional. Metabolomic profiling identifies biochemical pathways. This document is aec 390, one of a series of the department of agricultural education and communication, ufifas extension.
The first version of oncomine was released in october 2003, with 40 microarray data sets and nearly 100 differential expression analyses, allowing users to query differential expression results for a gene of interest across collected data sets. A meta analysis of the 40 data sets identified a universal cancer signature, representing genes significantly overexpressed. The concept summary map present a view of all significant associations of the. Identify a main theme and then brainstorm for all related key words or phrases. The theory underlying concept maps and how to construct. A secondary analysis of a concept map to define to leadership needs was conducted using social network analysis. F left panel, oncomine concept map analysis illustrating the enrichment network between androgendependent. John steinbeck concept mapping is a generic term that describes any process for representing ideas in pictures or maps. Kelch repeat and nfe2l2 binding domain subject count figure 4. To this end, we measured levels of 150 metabolites and examined the rate of utilization of 184 metabolites in metastatic androgendependent prostate. To navigate a network of associations, we developed an analysis platform, the molecular concepts map.
Oncomine reportertogene mapping was used to identify the genes in each concept. Huycke, ms, aprn, bc abstract nursing theory challenges students to think abstractly and is often a difficult introduction to graduate study. Think of it as a translation between words and visuals a way of jumping from a set of written requirements to an initial design schema. A summary of literature pertaining to the use of concept mapping techniques and technologies for education and performance support the institute for human and machine cognition 40 s. Keap1 mutations and domain map identifies a number of mutations enriched in domains required for nfe2l2 repression r470 v155 r260 r272 btb homodimerization domain. Concept map for biology themes free pdf file sharing. When youre done, you can group words that go together with a circle or box. The 36 genes not otherwise implicated in erk signaling see fig. Our analysis has identified the genes, pathways, and networks deregulated across 18,000.
Whether the concept map is organized hierarchically or not, creating one requires students to deeply think through the components of a topic. A metaanalysis pdf a summary of literature pertaining to the use of concept mapping techniques and technologies for education and performance support. This link to a heat map view is available for all oncomine derived analyses. But a concept map is actually a highly effective notetaking strategy. Iuli, university of rochester, usa gustav hellden, kristianstad university, sweden email. A search on any gene returns a differential activity map, a visual summary of all the. You get a couple and learn how to handle them, and pretty soon you have a dozen.
Oncomine concepts map analysis has identified enrichment of. One of the strengths of using concept maps in qualitative research is that it allows the researcher to reduce the data in a meaningful way. Concept map format editable concept diagram template on. The enriched pathways were then examined insilico for their association with treatment failure i. Using concept maps in the data reduction process, allows for the visual identification of themes and patterns. Discovery of novel cancer genes through application of clinical. See resources for a list of concept mapping software. By using maps it is possible to display an average 20 page interview transcript on a single page. Hierarchy concept map the hierarchy concept map presents information in a descending order of importance. At first glance, a concept map looks like doodling or just a page with circles and lines. Metabolic data were used to derive biochemical pathways that were enriched in crpc, using oncomine concept maps ocm. Manual module3 v43 cancer biology and therapeutics program. Th e selection of shapes is the choice of the creator of the concept map.
Traditionally, concept analysis is useful in facilitating this abstract thinking. Molecular concepts analysis links tumors, pathways. Concept map the concept map below is a way for you to show relationships between words and concepts. Primary concept top 1% overexpressed in high grade, invasive breast cancer. Concept maps can provide one strategy to deal with the methodologic challenges of qualitative research. An arrow connecting two words shows that those words are related in some way. A concept map is a schematic device for representing a set of. Integrative molecular concept modeling of prostate cancer progression. Analysis and figure taken from the gemma cell line dataset in oncomine concepts edition q4, 20 data release. Concept maps were initially developed as a data analysis tool in novaks research program. A similar enrichment network of amino acid metabolism was also identified by the bioinformatics tool oncomine concept map 4, 5 ocm. Many of these products are easy to use and available at a reasonable cost.
The methods and the implications for supplementing the analysis of concept maps and debriefing results with stakeholders are discussed. We provide default thresholds for the concept analysis association results. Integration of regulatory networks by nkx31 promotes androgen. Concept maps show relationships between concepts in a way similar to how road maps represent locations of highways and towns.
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